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Background: Spinal anaesthesia is the frequently used central block used in a surgical procedure. Differentlocal anaesthetic drugs used in spinal anaesthesia differ in their analgesic property, lipid solubility, proteinbinding, pKa, and degree of spread, the baricity of solution being one of the primary determinants of spreadof solutions.Aims: To compare and evaluate the anaesthetic profile of preservative free 0.5% isobaric ropivacaine andbupivacaine in patients undergoing lower abdominal surgeries.Materials and Methods: The clinical study enrolled 100 patients posted for lower abdominal surgeriesunder spinal anaesthesia. All the patients were then randomized and received either isobaric preservativefree 3ml(15mg) of 0.5% bupivacaine (Group A, n=50) or 3ml(15mg) of 0.5% ropivacaine (Group B, n=50).Onset and duration of sensory and motor blocks, haemodynamic changes and any other side effects werenoted.Results: Demographic variables between the two groups were not significant. Onset of sensory block wasdelayed in ropivacaine group B (4.80 0.92 vs 4.35 0.88 min, p was found to be significantly more in group A (170.29 14.14 vs 155.77 13.97min, p group B. Onset of motor block was also earlier in group A than group B with p value duration was significantly shorter in group B (140.08 16.58 vs 160.95 15.74min). The two groupswere comparable in maximum level of blockade reached and haemodynamic parameters. Incidence ofhypotension and bradycardia was significantly less in ropivacaine group.Conclusion: This study establishes that ropivacaine produces good sensory block and is more stablehemodynamically with lesser side effects.Keywords: Ropivacaine isobaric, Isobaric bupivacaine, Baricity, Intrathecal.

indian journal of clinical anaesthesia

Comparative evaluation of intrathecal preservative free isobaric 0.5% ropivacaine with isobaric 0.5% bupivacaine in patients undergoing lower abdominal surgeries