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and Objectives: Hypotension after spinal anaesthesia (SA) for a cesarean section maysometimes lead to significant consequences in mother and may also lead to a compromise in neonataloutcome. The objective of this study was to compare the effects of prophylactic Ephedrine andPhenylephrine to prevent hypotension, nausea, and vomiting, along with the possible changes in fetaloutcome.Materials and Methods: After approval from the institute and with informed consent, 100 parturientsundergoing cesarean section under SA, and who satisfied the inclusion criteria were divided into twogroups. All patients received 10 mg of 0.5% Bupivacaine heavy for SA, and the drug was injected at theL3-4 level. All parturients were co-loaded with Ringer’s lactate (RL), and either 100mcg Phenylephrineor 6mg Ephedrine was added in the RL solution. Occurrences of maternal hypotension, nausea, vomiting,and APGAR score for neonate were noted and compared.Results: Phenylephrine group had a significant reduction in the incidence of hypotension. However, itdid not translate into any significant reduction in the incidence of nausea or vomiting. There were alsosignificant differences in the APGAR scores of the neonate in 1 and 10 minutes; Phenylephrine group hada better outcome as compared to Ephedrine group.Conclusion: Prophylactic Phenylephrine 100 mcg added to co-loading crystalloid prevents maternalhypotension significantly more than prophylactic Ephedrine 6 mg. The fetal outcome in terms of APGARscore was also better in the Phenylephrine group. However, there was no difference in the maternal heartrate, nausea, and vomiting among the groups.Keywords: Phenyl ephrine, Ephedrine, Spinal hypotension, Cesarean section.

indian journal of clinical anaesthesia

Effect of prophylactic phenylephrine and ephedrine added to the co-loading solution on maternal hypotension, nausea and vomiting in patients undergoing caesarean section in a remote Indian Island