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and Aims: Pain relief after knee arthroscopy is preferred for early recovery and mobility. We aim to compare effectiveness and safety of different doses of morphine 5mg and 10mg combined with 0.5% bupivacaine given intraarticularly after knee arthroscopy for postoperative analgesia. Materials and Methods: This prospective, double blind study was done in 80 patients of either sex, undergoing elective diagnostic / therapeutic arthroscopic knee surgery under spinal anesthesia. Patients were randomly allocated to two groups. 20 ml of 0.5% Bupivacaine with 5 mg, 10 mg morphine as additive were injected intra-articularly in Group 1 and Group 2 respectively. Postoperative analgesia was assessed by Visual Analogue Scale at the 1st, 2nd, 4th, 6th, 12th, 18th and 24th after surgery. Time of the first request of rescue analgesia when VAS>4, total rescue analgesic consumption and any side effects in first 24 hour postoperatively was recorded. Results: Time of first postoperative rescue analgesic was significantly longer in Group 2 (464.88 ± 25.00 min) compared to Group 1 (442.75 ± 39.79 min). Post-operative VAS score was significantly lower at 6th, 8th, 12th and 24th hour in Group 2. Total dose of analgesic used in 24 hours in Group 2 was significantly lower than Group 1. Few side effects noted in both groups were comparable. Conclusion: We conclude that intraarticular dose of 10mg Morphine is better than 5mg Morphine with 20 ml of 0.5% Bupivacaine as it provides better postoperative analgesia with longer duration and minimal side

indian journal of clinical anaesthesia

Comparison of postoperative analgesia after intraarticular injection of two different doses of morphine (5 mg) and Morphine (10 mg) with 0.5% bupivacaine in arthroscopic knee surgery : Randomized, double blinded prospective study