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Background and Objective: Laryngoscopy and endotracheal intubation employed for generalanaesthesia cause noxious stimuli and are associated with laryngo- sympathetic stimulation manifestedby hypertension, tachycardia and arrhythmias. This study compares the efficacy of dexmedetomidine andfentanyl in attenuating haemodynamic stress responses to laryngoscopic endo-tracheal intubation in adultpatients undergoing surgeries under general anaesthesia.Materials and Methods: 90 adult participants of any sex aged between 18-55yrs undergoing electivesurgeries under general endo-tracheal anaesthesia were divided into 3 groups of 30 patients in each group.Group C: Control group – received 10ml of normal saline (NS) intravenously (IV) over 10 minutes (min),10min before induction. Group D: Dexmedetomidine group - received IV Dexmedetomidine 0.6mg/kgbody weight diluted to 1 0ml of NS IV over 10min using a syringe pump and 3ml of NS IV 2min beforeinduction. Group F: Fentanyl group - received 10ml of NS IV over 10min using a syringe pump and IVFentanyl 2mg/kg body weight diluted to 3ml of NS IV 2min before induction. Anaesthesia was inducedwith IV Thiopentone sodium 5 mg/kg body weight and IV Vecuronium 0.1mg/kg body weight to facilitateendotracheal intubation. Lignocaine 1.5mg/kg IV was given 90seconds before intubation in all the groups.Anaesthesia was maintained with Oxygen, Nitrous Oxide, 1-2% Sevoflourane and IV Vecuronium. Heartrate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP)were recorded at various time intervals.Results: In group C, 1min after laryngoscopy and intubation, the rise in HR, SBP, DBP and MAP were42bpm, 30mmHg, 22 mmHg and 24mmHg respectively compared to basal values. In group F, 1min afterlaryngoscopy and intubation, the rise in HR was 14bpm, rise in SBP, DBP and MAP each by 2mmHgcompared to basal values. In group D, HR, SBP, DBP and MAP were decreased by 4bpm, 23 mmHg,25mmHg and 24

Intravenous dexmedetomidine versus fentanyl to attenuate haemodynamic stress response to laryngoscopy and endotracheal intubation