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Aim: The objectives of this study were to: 1) establish a nuclear grade evaluation method for endometrioidcarcinoma, and 2) evaluate the nuclear grade of each part in cases in which glandular and solid parts arepresent within the same tumor, and confirm its correlation with clinicopathological factors, through whichthe usefulness of this nuclear grade evaluation method was assessed.Material and Methods: Samples were 19 preparations of specimens (4 endometrium in proliferationphase, 8 endometrioid carcinoma G1 and 7 G3 cases) in HE-stained histological preparations (2-mm thinsections). The nuclear grade evaluation method for endometrioid carcinoma comprises 6 items of thenuclear atypia index and each item is scored 1-3. The nuclear grade (NG) was classified as follows basedon the total score (6-18 points): NG-I, 6-10; II, 11-13; III, 14 -18. Then, in cases in which glandularand solid parts were present within the same tumor, the nuclear grades of these parts were separatelyevaluated. The nuclear grade pattern (glandular and solid part-nuclear grade score pattern: GS-NG pattern)was classified into 4 types: GS-NG patterns 1-4. The highest NG score in each case, designated as “ casenuclear grade (Case-NG) ”, was positively correlated with p53 expression, and two patients who died ofprimary disease were Case-NG III.Conclusion: Histological nuclear grade evaluation method for endometrioid carcinoma, and thesignificance of separately evaluating nuclear atypia of the glandular and solid structure parts, was a usefulmethod.Keywords: Endometrium, Endometrioid carcinoma: EMC, Nuclear grade: NG, Case-nuclear grade: Case-NGGlandular and solid part-nuclear grade, score pattern: GS-NG

ip archives of cytology and histopathology research

Establishment of nuclear grade evaluation method for endometrial endometrioid carcinoma, and the significance of separately evaluating nuclear atypia of the glandular and solid structure parts