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Materials and Methods: A total of 263 knees, (150 patients), males 65, females 85 with early OA were divided randomly into two groups. Group A 75 patients (134 knees) received a single injection of PRP, group B 75 patients (129 knees) received 2 injections of PRP 3 weeks apart. PRP with a platelet count 5 times that of baseline was administered in all. Clinical outcome was evaluated using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire before treatment and at 1 month, 3 month, and 6 months post injection. A reduction in WOMAC score is suggestive of improvement in patient condition. Results: significant improvement in all WOMAC parameters was noted in groups A and B within 3 to 4 weeks and lasting until the final follow-up at 6 months. The mean WOMAC scores (pain, stiffness, physical function, and total score) for group A at baseline were 15.8, 6.22, 43.09, and 65.11, respectively, and at final follow-up were 4.83, 1.00, 14.12, and 19.95, respectively, showing significant improvement. Similar improvement was noted in group B (mean WOMAC scores at baseline: 16.51, 6.91, 41.98, and 65.38, respectively; mean WOMAC scores at final follow up: 5.50, 1.12, 13.69, and 20.37, respectively . The 2 groups were compared with each other, and no improvement was noted in group B as compared with groups A (P, value 0.77). Conclusion: Autologous PRP infiltration in early Osteoarthritis of Ahlback’s radiological grading does give relief from pain, stiffness and improves functionality without any major side effects. Double dose doesn’t offer any additional advantage.

indian journal of orthopaedics surgery

A Randomised control study on effects of autologous platelet rich plasma injection in early osteoarthritis knee by single dose versus double dose regimen