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Coronary artery disease (CAD) is the leading cause of death worldwide. Deranged lipid metabolism is one of the important factors leading to development of myocardial infarction (MI). The study was designed to determine and correlate conventional lipid parameters and novel lipid atherogenic indices with serum CKMB in subjects presenting with MI at a tertiary care hospital. Materials and Methods: The study comprised of 50 subjects presenting with MI as cases and 50 age & sex matched, non-diabetic subjects as controls. Data related to serum CKMB levels were collected. Fasting venous blood samples were analysed for lipid profile. Non HDL and various other lipid ratios such as TG/HDL, Atherogenic Index of Plasma (AIP), Castelli Risk Index (CRI I & II) and Atherogenic Coefficient (AC) were calculated. Comparison between cases and controls was done using Student’s t test. Correlation between CK MB with lipid parameters was done using regression analysis. Statistical significance was considered as p < 0.05. Result: Serum CKMB levels in MI patients were significantly increased (p < 0.001). All the lipid parameters except HDLc were significantly increased among cases with MI (p<0.001). All the calculated ratios were found to be significantly elevated in cases (p<0.001) as compared to controls. A positive correlation was found between non-HDL, sdLDL and CRI II with CKMB. Conclusion: The findings of this study conclude that assessment of lipid profile and lipid ratios even in a normal individual is important as they are considered as atherogenic factors for the development of myocardial infarction and other coronary complications.

Serum CK-MB, fasting lipid profile and lipid indices in patients with myocardial infarction -A case control study