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Ondansetron is widely used perioperative antiemetic. In this study, we have assessed the anti-emetic efficacy of orally disintegrating film (ODF) in middle ear surgeries, associated with higher incidence of PONV. Materials and Methods: We studied two doses of ODF (4 and 8 mg) and compared it with IV ondansetron and placebo. All 120 cases were done under general anesthesia with standard anesthesia technique. Results: Oral intake was significantly delayed in placebo group. (p= 0.001) During first 6hrs, the PONV score was significantly low (p<0.001) in ODF4 and ODF8 group as compared to placebo group, however there was no difference in the intravenous group. In 6-24hr interval, all the groups were comparable. Also, there were no side effects in any patient in any group which required treatment. Conclusion: We conclude that all patients undergoing surgeries of middle ear should receive prophylactic antiemetic. Ondansetron in the form of orally disintegrating film is an effective as well as safe choice for PONV prevention in middle ear surgery with 8 mg to be the desired dose as compared to placebo and IV ondansetron.

indian journal of clinical anaesthesia

Efficacy of orally disintegrating film vs intravenous ondansetron in preventing postoperative nausea and vomiting in middle ear surgeries under general anaesthesia