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Bu calismada, losartan potasyum ve indapamide ilaclarinda gama radyasyonu ile olusturulan serbest radikallerin dogasi elektron paramanyetik rezonans (EPR) spektroskopisi kullanilarak oda sicakliginda belirlenmistir. Bu orneklerin EPR spektrumlari sirasiyla CHĊHCH 3 ve ĊHCHCH 3 NH radikallerine atfedilmistir. Serbest radikallerin asiri ince yapi sabitleri ve g-degerleri hesaplanmistir. EPR olcumleri radyasyondan sonra olusan paramanyetik merkezin kararliligi ve spin yogunlulugunun absorplanan radyasyonun dozuna bagli oldugunu gostermistir. Her iki ornekte olusan paramanyetik merkezler orneklerin kimyasal yapisi goz onune alinarak belirlenmistir. Iki materyalin manyetik ozellikleri ve paramanyetik merkezin mumkun yapisi bu calismada tartisilmistir.

erzincan üniversitesi fen bilimleri enstitüsü dergisi

Investigation of Paramagnetic Center Formed by Gamma Radiation in Losartan Potassium and Indapamide Drugs Used in Cardiovascular Treatment with EPR Spectroscopy