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The aim of this research is to study the kinetic models of Clindamycin hydrochloride encapsulated in poly(D,Llactic-co-glycolic acid) particles (CLH/PLGA). The CLH/PLGA particles were prepared by the double emulsion technique. The characterizations of CLH/PLGA particles were determined particle size, zeta potential, encapsulation efficiency, morphology, principle functional group, swelling, and in vitro drug release profile. The morphology of CLH/PLGA particles was the smooth and spherical shape. The maximum encapsulation efficiency of CLH/PLGA particles was 75% and the particle size of CLH/PLGA particles is from 216 to 222 nm and zeta potential value from -14.7 to -12.76 mV. The in vitro release of CLH/PLGA particles was carried out in pH 6.8 and pH 7.4. The model drug release profile result was fitting with the kinetic mathematic model. In addition, the kinetic models of CLH/PLGA particles released in pH 6.8 and pH 7.4 were First order model and Korsmeyer-Peppas model. The investigated of the kinetic model also gave a better of the effect on the CLH release pattern.

Study Kinetics Models of Clindamycin Hydrochloride from Poly(D,L-lactic-co-glycolic acid) Particles