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—Gelatin/CMC mixture was used to produce nanofiber scaffold in order to analyze fiber’s physical characteristic. The gelatin solution made from dissolving gelatin in water which serves as solvent for the solution because water is a great solvent for gelatin. However, the solution used in fiber production with electrospinning, this research used organic solvent, 2,2,2-trifluoroethanol, which is also a good solvent for gelatin and hence produces good raw material for fiber production using electrospinning. However, since CMC was unable to dissolved under organic solvent like 2,2,2-trifluoroethanol, it was dissolved in water instead. The weight ratios of the gelatin/CMC mixture are 100/0, 90/10, 80/20, 70/30 and 60/40, respectively. Whereas higher or lower concentration of the solution resulted in failure to produce the fiber by using electrospinning. After nanofiber was produced, the size of the fiber was between 36-563 nm and this research also found that the scaffold of the 60/40 mixture occurred the smallest fiber with average fiber size of 41 nm which contained white granules in its structure. Water absorption analysis of fiber revealed that 100/0 mixture scaffold had the highest rate of absorption which was 11.79% and average lower swelling ratio of 62.7% in comparison with swelling ratio of the scaffold from freeze dry technique.

Characterization of Gelatin/CMC Scaffolds by Electrospinning and Comparison with Freeze Dry Techniques