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The patient was a 3-year-old boy with a previous history of atopic dermatitis, bronchial asthma, allergic rhinitis, and food allergy. He was born at term via vaginal delivery and was breastfed from birth. At 3 months of age, he was diagnosed with atopic dermatitis and treated with moisturizer and topical corticosteroids. At 3 years of age, a few minutes after administration of olopatadine hydrochloride (ALLELOCK Granules 0.1%), he experienced an unusual sensation in the pharynx, followed by urticaria and cough 10 minutes later. Generalized urticaria developed, and coughing became exacerbated. These symptoms improved in 3 hours without medical treatment. Two months later, the patient was treated for cavities after induction of anesthesia via xylocaine pump spray 8% at a dental office. He vomited 30 minutes after the end of treatment and rapidly developed generalized urticaria and repetitive vomiting, which required medical treatment in the emergency department. He recovered in the emergency department after oral administration of loratadine (Claritin Dry Syrup 1%). Subsequently, he sometimes developed urticaria when he applied diphenhydramine hydrochloride cream (Restamin KOWA Cream 1%), lidocaine cream (EMLA Cream 5%), or heparinoid lotion (HIRUDOID Lotion 0.3% or BESOFTEN Lotion 0.3%). Although he was required to continue dental treatment, the cause of the allergic symptoms was unclear. He came to our hospital for diagnosis of the cause of these recurrent hypersensitivity reactions. Causal relationships were established between the onset of symptoms and the use of ALLELOCK Granules 0.1% and Restamin KOWA Cream 1%. Furthermore, the patient had previously undergone a skin prick test (SPT) with these drugs at another hospital. As the SPT yielded a positive result, we performed an open patch test with the basic ingredients and additives of both drugs, which were provided by the manufacturers. A wheal with itching appeared 10 minutes after application of macrogol to the skin; the result was classed as positive. We considered macrogol to be the cause of his hypersensitivity reaction and examined the relationship between clinical symptoms and the presence or absence of macrogol in the drugs Recurrent Immediate Type Hypersensitivity Reaction Induced by Macrogol in a 3-Year-Old Boy