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Proton pump inhibitor–responsive esophageal eosinophilia (PPI-REE) and eosinophilic esophagitis (EoE) are clinically undistinguishable entities [1-3]. Component-resolved diagnosis enables simultaneous assessment of specific IgE antibodies to various allergens and could provide us with more accurate information about sensitization profiles in these patients [4-6]. The aim of this study was to compare the molecular sensitization profiles of patients diagnosed with EoE and PPI-REE. We performed a retrospective cross-sectional study. The study population comprised patients followed up at the Allergy Department of Hospital Universitario La Paz, Madrid, Spain with EoE and specific IgE measured by immuno-solid-phase allergen chip (ISAC, Thermo Fisher Scientific). The patients were recruited between January 2000 and December 2014. EoE and PPI-REE were confirmed according to guidelines [1]. Patients in whom eosinophils were not limited to the esophagus were excluded. The study protocol was reviewed and approved by Hospital La Paz Research Ethics Committee (PI-2012). We retrospectively collected demographic variables (sex, age), data on atopic background (allergic rhinitis and/or conjunctivitis, asthma, food allergy, and atopic dermatitis), medical data (celiac disease, Helicobacter pylori infection), and clinical characteristics. Skin prick tests (SPTs) were performed with a specially designed panel for EoE, which included food extracts, aeroallergens, Anisakis simplex, and latex. A wheal diameter ≥3 mm larger than the negative control was considered positive. Serum total IgE, tryptase, eosinophil cationic protein, and peripheral eosinophils were measured. The statistical analysis was performed with IBM SPSS statistics for iOS, Version 20.0 (IBM Corp). Sixty-one out of 82 patients with EoE who had undergone component-resolved diagnosis completed the PPI trial. PPI-REE was confirmed in 42.6% of patients and EoE in 57.4%. EoE and PPI-REE patients had similar demographic Manuscript received April 9, 2018; accepted for publication June 14, 2018.

Molecular Sensitization Profile According to Proton Pump Inhibitor Response in Patients With Esophageal Eosinophilia