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vi LIST OF TABLES  x LIST OF FIGURES  xi LIST OF ABBREVIATIONS xii CHAPTER ONE: INTRODUCTION  1 CHAPTER TWO: LITERATURE REVIEW  5 The Effect of Exercise on the Progression of Alzheimer’s Disease  5 Exercise Increases Brain Volume and Function  6 Exercise-Induced Changes in Aβ/tau are Unknown 7 Development of Alzheimer’s Disease  9 Alzheimer’s Disease Leads to Declines in Muscular Strength and Motor Control . 9 Both Amyloid Beta Plaque and Tau Protein Tangles Play a Significant Role in AD  13 The Rat Model of AD, TgF344-AD Closely Mimics Human Pathology  16 Significant Sex Differences are Present in the Development of AD  19 Purpose of the Research Study  22 CHAPTER THREE: MATERIALS AND METHODS  24 Animals  24

Early Changes in Memory, Motor Coordination and Strength in the Transgenic Rat Model of Alzheimer’s Disease, TgF344-AD