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We investigated the levels of biogenic monoamines and their metabolites in the rat hypothalamus, midbrain  and cerebellum in acute complex intoxication with morphine and alcohol. The distinctive features of neurotransmitter  disorders in various parts of the rat brain under a single exposure to ethanol and morphine, as well as the differences  between acute morphine-alcohol and alcohol-morphine intoxication were established. Complex intoxication with  alcohol and morphine resulted in signs of dopamine consumption only in the hypothalamus, regardless of the order  of alcohol and morphine administration. Under conditions of alcohol-morphine intoxication an increase in the level  of metabolites of the serotonergic system was noted in the investigated parts of the brain. In the midbrain and  cerebellum the manifestation of combined action of ethanol and morphine is mainly determined by the effect of the last  of the administered substances. There are features of changes in the indices of the dopaminergic and serotonergic  systems in these experimental conditions, confirmed by the processes of dopamine catabolism and a decrease  in the norepinephrine and serotonin concentration in the hypothalamus, which are not observed under individual action  of ethanol and morphine.

Neurotransmitter changes in the rat brain under combined intoxication induced by alcohol and morphine