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Ionotropic glutamate receptors of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype  play a key role in synaptic plasticity representing one of the mechanisms for learning and memory formation.  They can also serve as targets for the development of novel classes of pharmaceuticals for the treatment or substantive  correction of many serious neurodegenerative and psychoneurological disorders. The search and studies of various  types of AMPA receptor ligands attract considerable attention from academic organizations and pharmaceutical  companies all over the world. This review mainly focuses on recent advances in this field. The architecture and  operational mechanism of the receptor as well as its major binding sites and ligand types are considered. Special  attention is paid to the studies of mechanisms of action and novel chemotypes of AMPA receptor agonists and  competitive antagonists, positive and negative allosteric modulators, auxiliary protein-dependent allosteric modulators,  and ion channel blockers.

Ligands of the AMPA-subtype glutamate receptors: mechanisms of action and novel chemotypes