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We found that changes in the concentrations of tryptophan metabolites in the blood serum and in the intestinal  contents are one of the mechanisms for the formation of metabolic coupling in the system "macroorganism-intestinal  microbiota", which undergoes significant changes in the development of obesity. Although blood kynurenine remained  basically unchanged in obese children we found an increase in some of its serum metabolites: anthranilic, kynurenic  and xanthurenic acids. It is noteworthy that in the analysis of fecal matter in obese children, revealed a 2-fold increase  in the level of kynurenine while the concentration of kynurenine pathway metabolites corresponded to the level  of the group of healthy children. This may indicate the metabolic activation of the microbiota associated with  the intestinal mucosa. This is also supported by the absence of statistically significant differences in the concentration  of indole in healthy children and in obese children in fecal analyses, and a significant increase in the concentration  of indole-3-lactate and indole-3-acetate in the blood serum of obese children.

The study of tryptophan metabolite concentrations in blood serum and fecal extracts from obese children