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The relative differences between post-translational modifications (PTM) of proteins in blood plasma samples  of patients with cerebral ischemia (CI) and healthy people were investigated using of the method of label-free  comparative proteomic analysis based on the technology of tandem HPLC-MS/MS. For PTM detection we used  multiple MS/MS search in the database Mascot for variable PTM and Progenesis LS-MS software. In the CI plasma  samples, we observed an increase in the proportion of peptides with such PTM as phosphorylation of serine, threonine,  and tyrosine, acetylation of lysine and protein N-term, ubiquitination of lysine and deamidation of glutamine related  to clinically significant processes were revealed.

Comparative analysis of post-translational modifications in plasma proteome of patients with cerebral ischemia based on HPLC-MS/MS method