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The effectiveness of three various combinations of an immunomodulator with an antioxidant and a membrane  protector in the correction of metabolic and immune disorders has been studied in the experiment under 60-days ethanol  intoxication. The development of such biochemical syndromes of the liver damage as cytolysis, intrahepatic,  intracellular cholestasis, toxic liver damage by necrotic type, insufficiency of synthetic processes and inflammatory  has been revealed. Oxidative stress development and the activation of lipid peroxidation on the systemic (blood plasma)  and local level (erythrocytes) have been established. Suppression of adaptive immunity formation and phagocytic  capabilities of neutrophils under the increase in their oxygen-dependent activity has been determined, which indicates  the presence and possible progression of the inflammatory process at the systemic level. A disorder of erythrocytes  metabolic activity, a decrease in stable metabolites of nitric oxide detected in blood plasma been revealed,  indicating its uncompensated consumption, causing vasoconstriction and thrombosis, which can additionally arise  due to the established increase in the prothrombin index. Combined use of “Longidasa”, “Mexicor”, “Essentiale forte N”  or “Glutoxim”, “Mexidol”, “Heptral” was more effective in the correction of immune-metabolic disorders in chronic  alcohol intoxication than “Hepon”, “Hypoxen” and “Phosphogliv”.

biomedicinskaâ himiâ

The use of immunomodulators, antioxidants and hepatoprotectors for the correction of the liver, erythrocites and the immune system disorders in chronic ethanol intoxication