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In connection with recent data about antiatherogenic importance of not only plasma HDL concentration,  but of their cell cholesterol efflux capacity as well, the possibility of its correction by phospholipid (PL) nanoparticles  was studied. Blood plasma was incubated with earlier elaborated PL nanoparticles emulsion with the particle diameter  up to 30 nm, and HDL cholesterol efflux capacity of apo B-depleted plasma was studied. Using macrophages  THP-1 preloaded 3H-cholesterol were used. The addition of incubated plasma supernatants with the elevated  PL/apo A-1 ratio to cell media resulted in almost increase in two fold 3H-cholesterol efflux as compared with native HDL.  The maximal efflux was observed at the PL/apo A-1 ratio of 1.06 as compared with native apo B-depleted plasma  (the PL/apo A-1 ratio of 0.85). Results suggest possible usage of ultrasmall PL nanoparticles for regeneration  of impaired antiatherogenic HDL functionality. This approach seems to be predominant compared with the usage  of PL emulsions with detergent or apoprotein A1.

Improving of HDL capacity for macrophages cholesterol efflux after plasma incubation with phospholipid nanoparticles