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One of the strategies to induce tolerance of neurons to toxic injury is preconditioning. Preconditioning  is caused by a weak damage of cells, which become more resistant to subsequent, more severe damage. We found  that preconditioning by deprivation of trophic factors, or deprivation of trophic factor and glucose effectively  protects neurons against subsequent toxic effects of glutamate. Deprivation of trophic factors plays a decisive role  in the development of resistance, regardless of whether it has been combined with glucose deprivation or not. Neuronal  protection is achieved when the deprivation lasts from 30 min to two hours and is kept for a period of from one to five  days. Preconditioning is accompanied neuronal secretion of cathepsin B occurs. We suggest that this phenomenon  is associated with a more general process of exocytosis of lysosomes triggered by deprivation of trophic factors.

Trophic factors deprivation induces long-term protection of neurons against excitotoxic damage