Open AccessPharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity
Author(s) -
А. А. Спасов,
Л. А. Смирнова,
O. Yu. Grechko,
A.I. Raschenko,
D. M. Shtareva,
В. А. Анисимова
Publication year - 2015
Publication title -
biomeditsinskaya khimiya
Language(s) - English
Resource type - Journals
eISSN - 2310-6972
pISSN - 2310-6905
DOI - 10.18097/pbmc20156105636
Subject(s) - pharmacokinetics , bioavailability , analgesic , derivative (finance) , pharmacology , medicine , agonist , chemistry , receptor , financial economics , economics
Pharmacokinetic properties of imidazobenzimidazole derivative compound RU-1205 were investigated after subcutaneous administration to rabbits as a substance and a dosage form (lyophilisates for injection) at a dose of 25 mg/kg. The lyophilisate was characterized by high values of the relative bioavailability. In tests, the “hot plate” and “vinegar cramps” the dosage form and the substance exhibited the same analgesic effect.
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