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Summary . The aim of this study was to investigate prevalence of genotypes and CCR2 gene alleles in patients with bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD). We examined 90 BA patients, 72 COPD patients and healthy subjects as controls using standard diagnostic tools for these diseases and molecular analysis. CCR2 chemokine receptor gene polymorphism was investigated in patients with BA and COPD in comparison with healthy subjects. There was not any significant difference in prevalence of genotypes and CCR2 gene alleles in patients with BA or COPD, or in controls. The results have shown an association between rare allele 641 in the CCR2 gene and COPD and a protective role for homozygous genotype 64V/64V of this gene in COPD development. The comparative analysis allowed extension our knowledge about some genetic features of these diseases. The CCR2 chemokine receptor gene polymorphism was associated with COPD but not with BA.

Analysis of CCR2 chemokine receptor gene polymorphism in patients with bronchial asthma and chronic obstructive pulmonary disease