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Background and Hypothesis: In the US alone, more than 160,000 men are diagnosed with prostate cancer each year. Prostate cancer grows slowly in many patients such that most die due to unrelated causes, yet 29,000 prostate cancer-related deaths occur annually in the US. The gravity of this mortality rate promotes over-treatment of lowand intermediate-risk cancer patients as well as monitoring of cancer via invasive biopsies to determine cancer grade. We hypothesize that molecular imaging methods can differentiate lowand intermediaterisk prostate cancer, guide optimal treatment, and eliminate morbidity associated with biopsy procedures.

Non-invasive estimation of prostate tumor grade with PET [68Ga] Ga-PSMA-11 imaging