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Experimental Design: Thirty-five paired 62Cu-ETS and H2O studies were performed in six Göttingen minipigs to validate the use of image-derived input functions. H2O estimates of tissue perfusion served as a reference standard for comparison with 62Cu-ETS. To demonstrate quantitative whole-body perfusion imaging in humans, paired 62Cu-ETS and H2O studies were performed in 14 renal cell carcinoma patients both prior to and following sunitinib therapy.

proceedings of imprs

A Clinically Suitable Approach to Whole-Body Imaging for Quantification of Regional Perfusion: Validation of Positron Emission Tomography (PET) with 62Cu-ETS and Image-based Tracer Kinetic Modeling