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Experimental Design and Project Methods: Diabetes was induced in four Ossabaw miniature swine by ablation of the insulin-producing pancreatic beta cells and 5 months later the pigs received 8 surgically-induced skin wounds. EXCEDE was given at the time of surgery to prevent systemic infections for the first week of wound healing. Wounds were treated with drug-loaded nanoparticles in a hydrogel, an unmodified hydrogel, Promogran Prisma Matrix, or control phosphate-buffered saline (PBS). Photos were taken weekly to compare wound closure and complete skin thickness biopsies were taken for histological assessment.

Wound healing in diabetic Ossabaw pigs