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A series of novel (1,2,3)-triazolyl substituted benzo(c)coumarins have been synthesized by reacting various 3-coumarinoyl methyl pyridinium bromide salts with 1-(5-methyl-1-phenyl-1H- 1,2,3-triazol-4-yl)ethanones in the presence of sodium acetate in refluxing acetic acid. The structures of the synthesized compounds have been elucidated by IR, 1 H-NMR, 13 C-NMR and Mass spectral data. All the synthesized compounds have been screened for their in vitro anti-bacterial and anti-fungal activities. Some of the compounds have been found to be active against some bacterial and fungal pathogens compared to standard drugs.

A Novel and Efficient Synthesis of [1,2,3]-Triazolyl Substituted Benzo[<i>c</i>]Coumarins and Evaluation of their Antimicrobial Activity