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In the present work Drude-dielectric formalism has been used to calculate the effects of contribution of inner and outer-electron shell to energy-loss of protons liquid water   and DNA . The results show that the incident protons with energy between (T = 0.05, 0.25, 1, 2, 2.5 MeV) are very efficient in producing secondary electrons in dry DNA , which are able to produce strand breaks and could be very effective for the biological damage of malignant cells. The PSPEC, Stopping power, average energy transfer, 〈∆〉 and ionization energy have been calculated taking in the consideration the Sub-shells of each elements in DNA and    , Fourier energy density (), Charge exchange and Screening effects (ᴧ). Good agreement achieved with the previous work [1].

Contribution of Outer Electron and Inner-Shell Electron to Proton Energy Loss in Liquid Water and DNA