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Various isopropylacetoacetanilides were treated with 4-(difluoromethoxy)-3-hydroxy benzaldehyde and thiourea/urea in the presence of acid catalyst to produce the 1,4-dihydropyrimidine derivatives (4a-5i and 5a-5i) with good yields. All the synthesized compounds were characterized by mass,  1 H-NMR and IR spectrum, also evaluated for antibacterial and antifungal activity against two Gram +ve and two Gram-ve bacterial and fungi strains. The compounds 4e, 4g and 5d were found comparatively promising active against all the bacterial and fungal strains.

international letters of chemistry, physics and astronomy

Synthesis, Antibacterial and Antifungal Activity of 5-Aryl Amido-6-Isopropyl-2-(Mercapto/Hydroxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl]-1,4-Dihydro Pyrimidine