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A new series of 2,5-distyryl-1,3,4-oxadiazoles derivatives have been synthesized from cinnamic hydrazide on reaction with various cinnamic acid derivatives. The structures of synthesized compounds have been elucidated by spectral studies like IR,  1 HNMR, Mass and also Elemental Analysis. Furthermore, all synthesized compounds were screened for I n Vitro  anti microbial activity against the gram positive ( Staphylococcus aureus ,  Pseudomonas aeruginosa ) and gram negative ( Escherichia coli ) bacterial strain. In which some the compounds show potential inhibition against the test organisms.

Microwave Assisted Synthesis of 2,5-Distyryl-1,3,4-Oxadiazole Derivatives as Anti Microbial Agents