English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The aim of the present study was to investigate the sedative and antidiarrheal activity of ethanol extract of C. appendiculata at the doses of 100 and 200 mg/kg body weight per oral (p.o) in Swiss albino mice. Sedative activity of the extract (100 and 200 mg/kg, p.o.) was assessed utilizing thiopental sodium-induced sleeping time model to evaluate sedative potential of the extract, hole cross to evaluate motor activity and open field test to evaluate exploratory behaviour. The extract also produced rapid onset and maximized the duration of sleeping time when administered with thiopental sodium. The extract fundamentally (p < 0.05-0.001) diminished motor action and exploratory conduct of mice in hole cross and open field test separately. In antidiarreal activity study, the concentrate (200 mg/kg) likewise demonstrated most extreme inhibition of defecation (90.64% and 80.95%) in both models individually. The present study demonstrates that the ethanol extract of C. appendiculata have central nervous system (CNS) depressant and antidiarrheal properties. In this manner, the plant may be further investigated to find for its pharmacological active natural products.

Investigations of Sedative and Antidiarrheal Activity of <i>Commelina appendiculata</i> in Swiss Albino Mice