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RESUMEN Introducción: el dengue presenta diversas formas clínicas, desde asintomáticas hasta fatales. Existen diversos factores de riesgo asociados a la mortalidad por dengue. Objetivo: determinar los factores de riesgo asociados a la mortalidad por dengue. Metodología: estudio de casos (adultos fallecidos por dengue) y controles (adultos sobrevivientes al dengue), durante la epidemia verano 2012-2013 en Paraguay. Resultados: los factores de riesgo asociados significativamente a la mortalidad por dengue fueron: presencia de comorbilidades, hemorragias, hepatitis, hipoproteinemia e hipoalbuminemia. El choque por dengue fue la causa de óbito más frecuente (49%). Conclusiones: los factores asociados a la mortalidad por dengue son inherentes al paciente (comorbilidades) y a la gravedad de la infección, resultante de las manifestaciones hemorrágicas, afectación sistémica y fuga capilar. Palabras claves: dengue, mortalidad, factor de riesgo, fuga capilar ABSTRACT Introduction: Dengue has several clinical forms, from asymptomatic to fatal. There are several risk factors associated with mortality from dengue. Objective: To determine the risk factors associated with mortality from dengue. Methodology: case studies deaths from adults dengue and controls (survivors dengue adults) during summer 2012-2013 epidemic in Paraguay. Results: Risk factors significantly associated with mortality from dengue were: presence of comorbidities, hemorrhage, hepatitis, hypoproteinemia and hypoalbuminemia. Dengue shock syndrome was the most common cause of death (49%). Conclusions: The mortality associated with dengue factors are inherent to the patient (comorbidities) and the severity of infection, resulting in hemorrhagic manifestations, systemic involvement and capillary leak.

Mortalidad en pacientes con dengue en la epidemia 2012-2013