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.. Objectives: To know the serum ferritin and vitamin B12 levels in relation to C reactive protein in individuals using smokeless tobacco in Hyderabad, sindh, Pakistan. Study Design: Cross sectional study. Place of Study: Private clinics of consultants of Hyderabad, Sindh, Pakistan. Duration of Study: January 2016 to February 2017. Methodology: One hundred eighty three individuals were selected from different clinics of physicians, dental surgeons of sadder Hyderabad sindh Pakistan by judgmental sampling. Patients were young subjects, mean age was 21.4±7.4 years, mean BMI was 22.1±3.8 and mean duration of chewing tobacco was 2±1.5 years. All types and forms of gutaka, manpuri and flavored betel nut were included like bombart, zafri and panparag. The dose was 30-100grams once or two times. SPSS 16 was used as statical software and Chai square test was used to calculate p value. P value was taken <0.05 statically significant. Results: Frequency of use of gutka was 32%, Betel nut 38% and 29% had habit of chewing manpuri. Serum ferritin was low and c reactive protein was high, p value was <0.05 in gutaka and manpuri users. Vitamin B12 was reduced significantly in gutaka user p value was <0.05. In betel nut chewers significant finding was only high C reactive protein, p value <0.04. Conclusion: Smokeless tobacco has significant negative impact on serum ferritin and vitamin B12 levels. These chewing agents also increased inflammatory markers like c reactive protein.

SMOKELESS TOBACCO; SERUM FERRITIN AND VITAMIN B12 IN RELATION TO C REACTIVE PROTEIN IN INDIVIDUALS. HYDERABAD SINDH BASED STUDY