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.. Introduction: Lichen amyloidosus (LA) is the major variant of the primary cutaneous amyloidoses which present with severe and therapy resistant itching. Various therapeutic modalities such as antihistamines, intralesional injection or topical application of corticosteroids, etretinate, UVB irradiation and dermoabrasion have been employed with variable success. Some authors have observed encouraging beneficial clinical effects by using topical dimethyl sulphoxide (DMSO). Objectives: The objective of the study was to: evaluate the efficacy of topical Dimethyl sulfoxide (D.M.S.O) 70% in Lichen Amyloidosis. Study Design: Case series. Settings: This study was conducted at dermatology department, Abbasi Shaheed Hospital in outpatient department (OPD). Duration of Study: The data collection was done in 06 months after approval of synopsis. From: 2nd June 2013 to 2nd December 2013. Results: In this study, out of 71 cases, 42.25%(n=30) were between 16-40 years while 57.75%(n=41) were between 41-80 years of age, mean+sd was calculated as 41.79+10.87 years, 26.76%(n=19) were male and 73.24%(n=52) were females, 36.62%(n=26) had <6 months and 63.38%(n=45) had ≥6 months of duration, frequency of efficacy of topical dimethyl sulfoxide (D.M.S.O) in lichen amyloidosis reveals 66.20%(n=47) while 33.80%(n=24) did not show efficacy. Conclusion: We concluded that the efficacy of topical Dimethyl sulfoxide (D.M.S.O) 70% in Lichen Amyloidosis is higher and in accordancde with other studies. It may be utilized in future for such cases.

LICHEN AMYLOIDOSIS; EVALUATION OF THE EFFICACY OF TOPICAL DIMETHYL SULFOXIDE (D.M.S.O) 70% IN ABBASI SHAHEED HOSPITAL, KARACHI