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The ratio of cardiovascular disease (CVD) in Pakistan is high as compare to western world and is one of the chief reasons of disability around the world. When CVD is diagnosed, following preventive measures should be taken which include regular exercise, proper diet, weight control and lipid reducing drugs to overcome the risk of morbidity or mortality. Primary hyperlipidemia is common factors for the progression and development of atherosclerosis and coronary heart disease. This study was designed to evaluate the effects of simvastatin and allium sativum (garlic) on lipid profile and to compare the lipid decreasing efficacy of simvastatin and herbal product of allium sativum in primary hyperlipidemic patients. Objectives: To evaluate the changes in lipid profile in patients with primary hyperlipidemia using original product of simvastatin and herbal product of the allium sativum (garlic). Study design: Cross-sectional study. Setting: The study was conducted at Surgeon Munawar Memorial Hospital, Karachi in year 2013 -2014. Material and Methods: Total of 60 patients of 30-70 years of age with abnormal lipid profile was enrolled for this study after a written consent. The patients were divided into group I and II with primary hyperlipidemia. Patients of group 1 and II were orally treated with simvastatin (20 mg)/day and allium sativum (garlic) (300 mg/day) for 8 weeks. All patients were evaluated before and after treatment with product of simvastatin and herbal product of allium sativum. Results: In this study the cholesterol, triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) were estimated in the serum of patients before and after treatment with Simvastatin (20 mg)/day and herbal product of allium sativum (garlic) (300 mg/day). It is observed in the present study that treatment with simvastatin significantly reduced the level of serum total cholesterol, triglycerides, LDL and increase serum HDL level. Allium sativum significantly reduces serum total cholesterol, serum LDL and increase serum HDL level in primary hyperlipidemic patients but there was no effect on triglyceride levels. Conclusion: We concluded that simvastatin significantly reduced the level of serum total cholesterol, triglycerides, LDL and increase serum HDL level and allium sativum significantly reduces serum total cholesterol, serum LDL and increase serum HDL level in primary hyperlipidemic patients but there was no effect on triglyceride levels.

PRIMARY HYPERLIPIDEMIC PATIENTS; DIFFERENCES IN LIPID PROFILE WITH ORIGINAL PRODUCT OF SIMVASTATIN AND HERBAL PRODUCT OF ALLIUM SATIVUM