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.. Objective: To determine the efficacy of Letrozole as a first line drug in sub fertile patients in term of pregnancy rate. Study Design: Case series study. Setting: Outpatient Department of Gynecology, Nishtar Hospital Multan. Period: May 2012 to December 2012. Material and methods: A total of 246 females with primary subfertility were enrolled in study from gynecological outpatient department. Results: Mean age of the patients was 25.92 ±3.93 years. 132 patients (54.0 %) had BMI of 2-25 kg/m2 and 101 patients (41%) had increased of BMI 26-30 kg/m2 and 13patients (5%) were obese and had BMI of >30 kg/m2. 42 patients (17%) were illiterate. 54 patients (22%) were primary to middle and 62(25%) were matric and 88(36%) were FSC and > than FSC. 39(16%) patients had monthly income 10,000 and 120(49%) patients had monthly income 10,000 -30,000 and 87(35%) patients had monthly income >30,000. Pregnancy was seen in 34% (83 patients). Conclusion: Aromatase inhibitors, Letrozole significantly increases pregnancy rate as a primary treatment in subfertility patients.

SUBFERTILE PATIENTS; EFFICACY OF LETROZOLE AS A FIRST LINE DRUG IN IN TERM OF PREGNANCY RATE