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Malaria is an infectious disease responsible for approximately one million deaths annually. Peptides such as angiotensin II (AII) and its analogs are known to have antimalarial effects against Plasmodium gallinaceum [1] and Plasmodium falciparum [2]. However, their mechanism of action is still not fully understood at the molecular level. In this work, we investigated this issue by comparing the antimalarial activity of angiotensin II with that of: i) its enantiomer formed by only D-amino acids; ii) its isomer with reversed sequence; and iii) its analogs restricted by lactam bridges the so-called VC5 peptides.

Mechanistic Proposal for Restricted Peptides Action on Parasite Membrane