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Many studies have shown that physical exercise improves multiple sclerosis (MS) symptoms, including cognition, fatigue, bowel and bladder function, depression, and overall quality of life. However, the pathophysiologic mechanisms responsible for these symptomatic changes remain elusive. Exercise offers a likely path for addressing progressive MS, nervous system repair, and as a wellness approach for people with MS. We as a community need to work toward gaining information to establish an evidence-based exercise prescription for people living with MS.

Exercise as Medicine in Multiple Sclerosis—Moving Beyond Compensatory Benefits