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Since the original conception and introduction of magnetic resonance imaging (MRI) gadolinium-based contrast agents (GBCAs) in the 1980s, many such contrast agents have been approved for use in contrast-enhanced MRI. These contrast agents have been used extensively in a large range of indications, particularly central nervous system examinations, as well as neurodegenerative diseases and tumoural disease processes, among others.

Are All Gadolinium-based Contrast Agents Similar? The Importance of High Stability, High Relaxivity and High Concentration