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Nos ultimos anos, as nanoparticulas de prata (AgNPs) tem atraido muita atencao devido as suas largas aplicacoes em diferentes campos como biotecnologia, microeletronica, armazenamento de informacao optica, medicina e conversao de energia. O presente trabalho teve como objetivo sintetizar nanoparticulas de prata a partir de amostras de mel de abelhas Apis mellifera produzidos na cidade de Santarem-Para, Brasil. Alem disso, avaliar a atividade antimicrobiana dessas amostras, obtidas em dois periodos distintos (seco e chuvoso), frente a patogenos de interesse clinico: Staphylococcus aureus, Staphylococus epidermidis e Cândida krusei. Todas as amostras apresentaram estabilidade, homogeinidade e diâmetro hidrodinâmico medio de 600 nm, tendo uma grande area superficial. Apresentaram indice de polidispersividade (PdI) medio de 0,36 e 0,28, utilizando meis do periodo seco e chuvoso, respectivamente. O potencial Zeta foi negativo para 5 amostras do periodo seco. As linhagens de S. aureus, S. epidermides e C. krusei foram sensiveis a todas as AgNPs sintetizadas, sendo que as CMI para S. aureus e S. epidermides variaram de 0,17 a 10,79 mg mL-1 e para C. krusei de 0,08 a 10,79 mg mL-1. De acordo com estudos as AgNPs sintetizadas se mostram mais ativas em bacterias Gram negativas do que Gram positivo. No entanto, os elevados valores de CMI obtidos neste trabalho estao associados aos maiores tamanhos das nanoparticulas sintetizadas.   Palavras-chave: Apis melifera. Staphylococcus aureus. Staphylococus epidermidis. Candida krusei. Abstract In recent years, silver nanoparticles (AgNPs) have attracted a lot of attention due to their wide applications in different fields such as biotechnology, microelectronics, optical information storage, medicine, and energy conversion. The present work aimed to synthesize silver nanoparticles from honey samples from Apis mellifera bees produced in the Santarem-Para, Brazil. In addition, to evaluate the antimicrobial activity of these samples, obtained in two distinct periods (dry and rainy), against pathogens of clinical interest: Staphylococcus aureus, Staphylococus epidermidis and Candida krusei. All samples showed stability, homogeneity and an average hydrodynamic diameter of 600 nm, with a large surface area. They had an average polydispersity index (PdI) of 0.36 and 0.28, using honeys from the dry and rainy periods, respectively. The Zeta potential was negative for 5 samples from the dry period. The strains of S. aureus, S. epidermides and C. krusei were sensitive to all synthesized AgNPs, with the MIC for S. aureus and S. epidermides ranging from 0.17 to 10.79 mg mL-1 and for C krusei from 0.08 to 10.79 mg mL-1. According to studies, the synthesized AgNPs are more active in Gram negative bacteria than Gram positive. However, the high MIC values obtained in this work are associated with the larger sizes of the synthesized nanoparticles.   Keywords: Apis mellifera. Staphylococcus aureus. Staphylococus epidermidis. Candida krusei.

Avaliação da Capacidade Antimicrobiana de Nanopartículas de Prata Sintetizadas com Mel de Abelha