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Figure 1: CRISPR mutations demonstrate that the mir-35-42 binding site in nhl-2 is not essential for development or fecundity. (A) Schematics depicting the region of the nhl-2 3’UTR containing two mutations affecting the mir-35-42 binding site. nhl-2(cdb114) is a 75-bp deletion encompassing the binding site, whereas nhl2(cdb29) is a mutation that reverses the sequence of the seed-binding site, thus abolishing predicted base pairing to mir-35 (or its family members mir-36-42). (B) Quantification of embryonic lethality and brood size in homozygous mutant nhl-2 lines as shown in (A).

The mir-35-42 binding site in the nhl-2 3'UTR is dispensable for development and fecundity.