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This study was conducted to examine the effects of saffron extract on preventing D-galactose and NaNO2 induced memory impairment and improving learning and memory deficits in amnestic mice. In this study, the learning and memory functions in ovariectomized mice were examined by the one way passive and active avoidance tests. In active avoidance test, training in amnestic treated (AT) and amnestic prophylaxis (AP) groups, was improved so that there was a significant difference between them and the amnestic control (AC) group. In passive avoidance test, animal's step through latency, as an index for learning, in all test groups was significantly greater than control group. Total time spent in dark room (DS), which opposes the memory retention ability, in AC was significantly greater than AT group at 1 and 2 hours after full training, while there was not any significant difference between this index in AP and AT as compared with normal control (NC) group. Our findings indicate that saffron hydro-alcoholic extract prevents and improves amnesia induced by D-galactose and NaNO2 in mice.

Saffron (Crocus sativus L.) extract prevents and improves D-galactose and NaNO2 induced memory impairment in mice