English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Free radicals are involved in the process of lipid peroxidation and play a cardinal role in numerous chronic diseases like cancer, coronary heart disease and ageing. Thus the ability to scavenge free radicals in order to minimize oxidative damage to living cells is very important. The hexane extract of Acalypha hispida (Burn F.) was screened for phytochemical constituents and was found to contain flavonoids, carbohydrates, phenols and alkaloids. Fractions obtained from chromatographic separation were screened for free radical scavenging activities using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and hydrogen peroxide. Out of the sixteen pooled fractions (S1-S16) screened, compounds S10 (91.8 %), S11 (93.8 %), S14 (92.5 %) and S15 (91.4 %) at a concentration of 0.1 mg/ml had significant antioxidant activities when compared to the known antioxidant ascorbic acid (90.9 %). However, in the analysis using hydrogen peroxide, S1 (99.5 %), S9 (99.2 %), S10 (95.4 %),S11 (95.8 %) and S15 (95.6 %) gave better activity than ascorbic acid (94.8 %), while only S1 and S9 were more effective than butylated hydroxylanisole (98.9 %) and α-Tocopherol (99.1 %) at the same concentration. The cytotoxicity analysis using the Brine Shrimp lethality test gave LC50 values greater than 1000 μg/ml for some of the fractions indicating very low level of toxicity. The better scavenging activity of A. hispida could be linked to the presence of secondary plant products like flavonoids and phenols, which have the ability to scavenge hydroxyl radicals, superoxide anions and lipid peroxy radicals.

Phytochemical investigation, cytotoxicity and free radical scavenging activities of non-polar fractions of Acalypha hispida (leaves and twigs)