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There are three required components of dynamic models for toxic effects: toxico kinetics, effects on a target parameter coupled to the internal concentration and the physiological component. The Dynamic Energy Budget (DEB) model, which is used to model the latter component, relates a change in a target parameter of a particular physiological process, such as the specific costs for growth, to an output variable, such as the cumulative number of offspring. We compare the logit/probit and the DEB-based models conceptually and numerically and conclude that the DEB-based model is more effective as an effect model. The DEB-based model solves the problem of estimating the No-Effect Concentration and provides the required information to evaluate the consequences of effects on individuals for population dynamics.

Report of the OECD Workshop on Statistical Analysis of Aquatic Toxicity Data