English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective:To assess the frequency and clustering of DNA fingerprinting (RFLP-IS6110), and to determine levels of drug- resistance among M. tuberculosis isolates from smear-positive pulmonary tuberculosis patients (SP-PTB) from a general hospital in Callao. Materials and methods: Patients with SP-PTB hospitalized in the Hospital Nacional Daniel A Carrion from August 2000 to February 2001were included in the study. Drug-susceptibilty testing to the four first-line drugs (INH, RIF, SM, EMB) was performed using the proportion method, and DNA fingerprinting analysis was performed using the standard IS6110-RFLP technique. Patient information was collected from clinical and laboratory records. Results: From 74 isolates, the number of IS6110-bands varied from 2 to 16, 4 isolates (5,5%) showed less than 5 bands. Overall, 50 DNA fingerprinting profiles were observed in 70 patients. 34 isolates (48,6 %) were grouped in 14 clusters and 36 isolates were isolated ocurrences. Drug resistance in never treated and previoulsy treated patients was 45,2% and 71,1%, respectively. Multidrug-resistance was 16,1% and 36,8%, respectively. 10 out of 14 clusters had at least one drug-resistant isolate. One cluster involved 6 drug-resistant isolates. Conclusion: No evidence of clonal spread of a particular strain was observed. However, we found clusters grouping drug-resistant and drug-susceptible patients. Our results suggests that there are genotypes associated with drug resistance, which could indicates ongoing transmission of drug-resistant M. tuberculosis strains in Callao. A population-based study is necessary to confirm our results.

revista peruana de medicina experimental y salud pública

Perfiles genéticos (RFLP-IS6110)y resistencia a drogas en aislamientos de M. tuberculosis de pacientes internados en un hospital referencial del Callao, Perú