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On April 22, 1921, the Moscow Medical and Prosthetic Institute was founded. Nikolay N. Priorov (MD, PhD, professor, academician of the USSR Academy of Medical Sciences) was the founder and permanent leader of the institute for 40 years. In 1930, the facility was renamed into the Moscow Regional Institute of Traumatology, Orthopedics, and Prosthetics. Before World War II, in 1940, the institute became known as the Central Research Institute of Traumatology and Orthopedics, known as CITO as the leading national institution for traumatology and orthopedics. For a century, CITO employees has been conducting clinical, research, educational, and methodological activities providing comprehensive assistance in all regions of the country. In 2018, CITO was the first traumatological and orthopedics centers to be transformed into the Federal State Budgetary Institution National Medical Research Center of Traumatology and Orthopedics named after N.N. Priorov of the Ministry of Health of the Russian Federation which significantly increased the role of the institution in traumatology and orthopedics, especially managemental, analytical, educational, and methodological activities. The 15 clinical departments and various laboratories of the center conducted research work and provide specialized medical care, including high-tech traumatological, orthopedic, oncological, and neurosurgical patient care.

Uniting the traumatological and orthopedical service of the country