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The effectiveness of hemantane, an original adamantane derivative, in combination with the dopamine receptor agonist piribedil on the model of acute parkinsonian syndrome induced by a single intraperitoneal injection of 30 mg/kg neurotoxicin-1, induced by a single intraperitoneal injection of 30 mg/kg neurotoxin 1-methyl-4-phenyl-tetrahydropyridine (MPTP) in C57BL/6 mice. Rigidity was assessed by stride length, oligokinesia and impaired coordination in the “rotarod test’’, effect on the catalepsy model caused by 0.1 mg/kg haloperidol. It has been established that the combination of hemantane and piribedil reduces the manifestations of parkinsonian syndrome, significantly exceeding in efficiency of each of the drugs separately.

The study of the effects of the combination of Himantane and Piribedil on a model of MPTP-induced parkinsonian syndrome in C57BL/6 mice