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The analysis of changes in the content of diene conjugation, fatty acid methyl esters (FAME) C20 of total lipids, fractions of free fatty acids (FFA) in the liver of animals exposed to overcooling for 3 hours and for 5 days after administration of cholinergic agents has been made. The obtained results indicate changing in the content of methyl esters of fatty acids and diene conjugation of FFA fractions after administration of pharmacological agents as neostigmine, pilocarpine, and atropine to animals on the background of cooling. Changes in the content of diene conjugation coincide with changes in the content of fatty acids (FA) C20 : 4 Δ-5,8,11,14 eicosatetraenoic acids (FA Arakhia) when pilocarpine or atropine was used. The presence of reciprocity was revealed. Basing the reciprocity factor, it was suggested that there was a possible effect of muscarine-sensitive structures of the plasmic membrane hepatocytes on the link between the content of FAME C20 Arakhia, phospholipase A2 activity and the change in the content of diene conjugation in fraction of liver FFA. A possible effect of cholinotropic agents on phospholipase A2 activity in the period of animal cooling was suggested.

obzory po kliničeskoj farmakologii i lekarstvennoj terapii

Pharmacological analysis of changes in the contentof diene conjugation, methyl esters of fatty acids of liver lipid fractions by cholinotropic agents during the overcooling of rats