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Aim. To study the influence of benzimidazole derivatives on the formation of oxidative stress under the impact of physical load. Materials and methods. Physical load (PL) was induced on intact outbred male rats by daily swimming for 21 days. Physical load, induced by swimming, is a convenient model of muscular work and it can be dosed. It, as a forced for rats procedure, caused stress, the development of which was controlled by changes in adrenal mass indices and blood leucocyte number in the animals. Results. The impaired behavioral reactions, decreased antioxidant activity in the liver and brain homogenates, elevated peroxidation product content, raised hemiluminescence intensity was detected. Conclusions. Negative manifestations of the developed psychoemotional and oxidative stress were restrained by the introduction of dibazol and synthesized potassium salt 2-[1-(1,1-dioxothietanyl-3)benzimidazolyl-2-thio] acetic acid.

INFLUENCE OF BENZIMIDAZOLE DERIVATIVES ON FORMATION OF OXIDATIVE STRESS UNDER PHYSICAL LOAD