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The State Pharmacopoeia of the Russian Federation 14th ed. suggests to standardize herbal teas using the procedures presented in the pharmacopoeia monographs but this approach is not always relevant due to complexity of this dosage form composition.&#x0D;The purpose of investigation is to estimate quality of herbal teas utilizing monographs recommended by the State Pharmacopoeia of the Russian Federation 14th ed. for the individual components of teas and suggest feasible alternative approaches to standardization of multicomponent herbal drugs.&#x0D;The objects of investigation  Pectorales species № 1 and Proctofitol. Detection of substances was carried out using chromatographic (TLC and HPLC) and spectrophotometric methods recommended by the State Pharmacopoeia of the Russian Federation 14th ed. for individual components measured in term of marker biological active substances or substances found in the course of quality analysis.&#x0D;It has been found out that the content of flavonoids measured in terms of giperosid surpasses over the equivalent figure in terms of luteolin in the extractions from Pectorales species № 1. The content of hydroxycinnamic acids in the same tea measured in terms of rosmarinic acid surpasses over the equivalent figure in terms of chlorogenic acid. Analysis of anthracene derivates in the Proctofitol has shown that the adsorption maximum of phenolate solution of anthracene derivates (523 nm) coincides with maximum by which was calculated the mass attenuation coefficient of sennoside B (523 nm) (for chrysophanic acid  = 515 nm) and the maximum of adsorption of extraction from the tea with using alcohol solution of magnesium acetate (515 nm) coincides with maximum by which was calculated the mass attenuation coefficient of glucofrangulin A. Preliminary cleaning Proctofitol off anthracene derivates allowed to estimate the content of glycyrrhizic acid more completely.&#x0D;The giperosid was suggested as a marker substance for determination of flavonoids, rosmarinic acid was suggested as a standard for hydroxycinnamic acids in Pectorales species № 1. The sennoside B was suggested as a marker for estimating of content of anthracene derivates in the Proctofitol and the necessity of cleaning this tea off anthracene derivates when defining glycyrrhizic acid was proven.

Determination of the marker compounds for standardization medicinal herbal species «Pectorales tea №1» and «Proctofitol»